Immunogen sequence: LEYVRTLYDF PGNDAEDLPF KKGEILVIIE KPEEQWWSAR NKDGRVGMIP VPYVEKLVRS SPHGKHGNRN SNSYGIPEPA HAYAQPQTTT PLPAVSGSPG AAITPLPSTQ NGPVFAKAIQ KRVPCAYDKT ALALEVGDIV KVTRMNINGQ WEGEVNGRKG LFPFTHVKIF DPQNPDE
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
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Protein Aliases: Crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like
Gene Aliases: CRKL
UniProt ID: (Human) P46109
Entrez Gene ID: (Human) 1399