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Invitrogen
DISC1 Polyclonal Antibody
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FIGURE: 1 / 5
DISC1 Antibody (40-6900) in ICC/IF
Immunofluorescence analysis of DISC1 was done on 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with DISC1 Rabbit Polyclonal Antibody (Product # 40-6900) at 1 µg/mL in 1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034) ... View More
Product Details
40-6900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from an internal region of the mouse DISC1 (disrupted in schizophrenia 1) isoforms 1 and 2, which differ from rat by one amino acid
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system, and is involved in neuronal functions that are dependent upon proper cytoskeletal regulation, including neuronal migration, neurite architecture and intracellular transport. Regions of the brain which express DISC1 include the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum and paraventricular hypothalamus, and loss of DISC1 function results in differences in structural organization.The DISC1 gene locus is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2, beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Disrupted in schizophrenia 1 homolog; Disrupted in schizophrenia 1 protein; RP4-730B13.1
Gene Aliases: C1orf136; DISC1; KIAA0457; SCZD9
UniProt ID: (Human) Q9NRI5, (Mouse) Q811T9, (Rat) Q810H6
Entrez Gene ID: (Human) 27185, (Mouse) 244667, (Rat) 307940
microtubule cytoskeleton organization
neuron migration
positive regulation of cell-matrix adhesion
positive regulation of neuroblast proliferation
multicellular organism development
nervous system development
protein localization
regulation of neuron projection development
positive regulation of neuron projection development
Wnt signaling pathway
cerebral cortex radially oriented cell migration
cell proliferation in forebrain
pyramidal neuron migration
positive regulation of Wnt signaling pathway
TOR signaling
cellular protein localization
nonmotile primary cilium assembly
cilium assembly
positive regulation of axon extension
mitochondrial calcium ion homeostasis
canonical Wnt signaling pathway
regulation of dendritic spine development
regulation of synapse maturation
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
response to electrical stimulus
protein localization to centrosome
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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