Product References
Immunohistochemical analysis of the monoclonal antibody 4B5 in breast tissue expressing human epidermal growth factor receptor 4 (HER4).
Histopathology
Jay JI,Brunhoeber PS,Smith MH,Williams RR,Sugarman MC,Free HL,Tast DE
MA5-13013 was used in immunohistochemistry to study the utility of the 4B5 monoclonal antibody for clinical HER2 status determination in breast tissue expressing HER4
Fri Mar 01 00:00:00 EST 2013
Slow down to stay alive: HER4 protects against cellular stress and confers chemoresistance in neuroblastoma.
Cancer
Hua Y,Gorshkov K,Yang Y,Wang W,Zhang N,Hughes DP
MA5-13013 was used in blocking or activating experiment to study the mechanisms underlying the modulation of neuroblastoma cellular stress and chemoresistance by HER4
Mon Oct 15 00:00:00 EDT 2012
Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Janssen MJ,Leiva-Salcedo E,Buonanno A
MA5-13013 was used in immunohistochemistry to study the direct effects of neuregulin on voltage-gated sodium channel activity of hippocampal interneurones expressing ErbB4
Wed Oct 03 00:00:00 EDT 2012
Decorin, erythroblastic leukaemia viral oncogene homologue B4 and signal transducer and activator of transcription 3 regulation of semaphorin 3A in central nervous system scar tissue.
Brain : a journal of neurology
Minor KH,Bournat JC,Toscano N,Giger RJ,Davies SJ
MA5-13013 was used in blocking or activating experiment to study the role of decorin in suppressing semaphorin 3A expression within adult rat cerebral cortex scar tissue
Fri Apr 01 00:00:00 EDT 2011
Populations of radial glial cells respond differently to reelin and neuregulin1 in a ferret model of cortical dysplasia.
PloS one
Poluch S,Juliano SL
MA5-13013 was used in blocking or activating experiment to investigate the influence of reelin and NRG1 on radial glia cells in ferrets
Thu Oct 28 00:00:00 EDT 2010
Heparin-binding epidermal growth factor-like growth factor is a potent neurotrophic factor for PC12 cells.
Neuro-Signals
Zhou Y,Besner GE
MA5-13013 was used in blocking or activating experiment to investigate the effect of heparin-binding epidermal growth factor-like growth factor on neuronal functions
Thu Feb 09 00:00:00 EST 2012
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.
Molecular and cellular biology
Proietti CJ,Rosemblit C,Beguelin W,Rivas MA,Díaz Flaqué MC,Charreau EH,Schillaci R,Elizalde PV
MA5-13013 was used in immunocytochemistry to investigate the role of Stat3 in the tumorigenic effect of heregulin/ErbB-2 in breast cells
Sun Mar 01 00:00:00 EST 2009
Diminished survival of human cytotrophoblast cells exposed to hypoxia/reoxygenation injury and associated reduction of heparin-binding epidermal growth factor-like growth factor.
American journal of obstetrics and gynecology
Leach RE,Kilburn BA,Petkova A,Romero R,Armant DR
MA5-13013 was used in blocking or activating experiment to study the role of HB-EGF as a survival factor in human cytotrophoblast cells exposed to hypoxia/reoxygenation injury
Tue Apr 01 00:00:00 EDT 2008
Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells.
Biology of reproduction
Wolff GS,Chiang PJ,Smith SM,Romero R,Armant DR
MA5-13013 was used in blocking or activating experiment to examine the anti-apoptotic effect of epidermal growth factor-like growth factors in human placental cytotrophoblast cells
Sun Jul 01 00:00:00 EDT 2007
Regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneurons.
Brain research bulletin
Longart M,Chatani-Hinze M,Gonzalez CM,Vullhorst D,Buonanno A
MA5-13013 was used in immunocytochemistry to study the role of neuregulin in modulating ErbB4 endocytosis in cultured hippocampal neurons
Thu Jul 12 00:00:00 EDT 2007
ErbB4 increases the proliferation potential of human lung cancer cells and its blockage can be used as a target for anti-cancer therapy.
International journal of cancer
Starr A,Greif J,Vexler A,Ashkenazy-Voghera M,Gladesh V,Rubin C,Kerber G,Marmor S,Lev-Ari S,Inbar M,Yarden Y,Ben-Yosef R
MA5-13013 was used in blocking or activating experiment and immunohistochemistry to study the role and therapeutic potential of ErbB4 in non-small-cell lung cancer
Sat Jul 15 00:00:00 EDT 2006
Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor.
Development (Cambridge, England)
Armant DR,Kilburn BA,Petkova A,Edwin SS,Duniec-Dmuchowski ZM,Edwards HJ,Romero R,Leach RE
MA5-13013 was used in blocking or activating experiment to study the role of metalloproteinase-mediated shedding of HB-EGF-like growth factor in human trophoblast survival at low oxygen concentrations
Wed Feb 01 00:00:00 EST 2006
Isolation of scFvs to in vitro produced extracellular domains of EGFR family members.
Cancer biotherapy & radiopharmaceuticals
Horak E,Heitner T,Robinson MK,Simmons HH,Garrison J,Russeva M,Furmanova P,Lou J,Zhou Y,Yuan QA,Weiner LM,Adams GP,Marks JD
MA5-13013 was used in western blot to develop and characterize specific antibodies targeting EGFR family
Thu Dec 01 00:00:00 EST 2005
An inhibitor of the EGF receptor family blocks myeloma cell growth factor activity of HB-EGF and potentiates dexamethasone or anti-IL-6 antibody-induced apoptosis.
Blood
Mahtouk K,Jourdan M,De Vos J,Hertogh C,Fiol G,Jourdan E,Rossi JF,Klein B
MA5-13013 was used in immunoprecipitation to study the effect of an epidermal growth factor receptor inhibibor on HB-EGF activity and apoptosis
Mon Mar 01 00:00:00 EST 2004
Signaling pathways required for matrix metalloproteinase-9 induction by betacellulin in head-and-neck squamous carcinoma cells.
International journal of cancer
O-charoenrat P,Wongkajornsilp A,Rhys-Evans PH,Eccles SA
MA5-13013 was used in blocking or activating experiment to investigate the mechanism of MMP9 induction by betacellulin in head-and-neck squamous carcinoma cells
Fri Aug 20 00:00:00 EDT 2004
Neuregulin expression, function, and signaling in human ovarian cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Gilmour LM,Macleod KG,McCaig A,Sewell JM,Gullick WJ,Smyth JF,Langdon SP
MA5-13013 was used in immunocytochemistry to investigate the characteristics of neuregulin in human ovarian cancer cells
Sun Dec 01 00:00:00 EST 2002
Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells.
Cancer research
O-charoenrat P,Modjtahedi H,Rhys-Evans P,Court WJ,Box GM,Eccles SA
MA5-13013 was used in flow cytometry to investigate the regulation of matrix metalloproteinase 9 by epidermal growth factor-like ligands in head and neck squamous carcinoma cells
Tue Feb 15 00:00:00 EST 2000