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FADD Polyclonal Antibody

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FADD Polyclonal Antibody

Product Details

BS-0511R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from mouse FADD, amino acids 1-80.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FADD; Fas (TNF receptor superfamily, member 6); Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; protein FADD; unnamed protein product

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Gene Aliases: FADD; GIG3; IMD90; MORT1; Mort1/FADD; TNFRSF6

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UniProt ID: (Human) Q13158, (Mouse) Q61160

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Entrez Gene ID: (Pig) 595129, (Human) 8772, (Mouse) 14082, (Rat) 266610

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Function(s)
protease binding death receptor binding tumor necrosis factor receptor binding protein binding protein binding, bridging tumor necrosis factor receptor superfamily binding receptor serine/threonine kinase binding signaling adaptor activity death effector domain binding identical protein binding macromolecular complex binding caspase binding protein complex binding
Process(es)
positive regulation of T cell mediated cytotoxicity immune system process positive regulation of adaptive immune response apoptotic process signal transduction T cell differentiation positive regulation of interferon-gamma production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production T cell differentiation in thymus TRAIL-activated apoptotic signaling pathway positive regulation of activated T cell proliferation regulation of apoptotic process T cell homeostasis positive regulation of apoptotic process innate immune response positive regulation of macrophage differentiation positive regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter lymph node development spleen development thymus development cardiac muscle tissue development protein heterooligomerization defense response to virus positive regulation of type I interferon-mediated signaling pathway negative regulation of necroptotic process negative regulation of activation-induced cell death of T cells motor neuron apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand activation of cysteine-type endopeptidase activity necroptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation positive regulation of extrinsic apoptotic signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling cellular response to mechanical stimulus positive regulation of cytokine production kidney development extrinsic apoptotic signaling pathway via death domain receptors response to cocaine positive regulation of innate immune response behavioral response to cocaine positive regulation of immune response regulation of necroptotic process death-inducing signaling complex assembly defense response to other organism positive regulation of execution phase of apoptosis
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