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Invitrogen
FIR Polyclonal Antibody
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Product Details
PA5-104510
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FARP2(Accession O94887), corresponding to amino acid residues S344-L394.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total FIR.
Target Information
FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FERM domain including RhoGEF (FIR), is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FERM domain including RhoGEF; FERM domain-including RhoGEF; FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2; FGD1-related Cdc42-GEF; FIR; PH domain-containing family C member 3; Pleckstrin homology domain-containing family C member 3; unnamed protein product
Gene Aliases: AI465173; BC009153; D030026M03Rik; FARP2; FIR; FRG; KIAA0793; mKIAA0793; PLEKHC3
UniProt ID: (Human) O94887, (Mouse) Q91VS8
Entrez Gene ID: (Human) 9855, (Mouse) 227377
cell adhesion
neuron remodeling
Rac protein signal transduction
osteoclast differentiation
actin cytoskeleton reorganization
regulation of integrin activation
regulation of Rho protein signal transduction
positive regulation of GTPase activity
semaphorin-plexin signaling pathway
podosome assembly
signal transduction
hair cycle process
actin cytoskeleton organization
cell development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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