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GABA(A) R beta-3 Polyclonal Antibody
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Product Details
OSG00084W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 300-400 of human GABA(A) receptor subunit beta-3 conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: GABRB3.
Target Information
Gamma-amino butyric acid (GAMA) is a strong inhibitor of neuron transmission and is found throughout the central nervous system. GABA is formed by the decarboxylation of glutamate, resulting in the formation of one of two distinct types; GABA-A or GABA-B.The binding of GABA to GABA-A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system overload can resulting in blackouts, rapid body contractions, seizures and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GABA-alpha receptor beta-2 subunit; GABAA receptor beta-3 subunit; GABAAR subunit beta-3; GABR B3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid A receptor beta 3; gamma-aminobutyric acid type A receptor beta3 subunit; gamma-aminobutyric acid type A receptor subunit beta 3; MGC9051; unnamed protein product
Gene Aliases: DEE43; ECA5; EIEE43
UniProt ID: (Human) P28472
Entrez Gene ID: (Human) 2562
transmembrane signaling receptor activity
GABA-A receptor activity
receptor binding
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
GABA-gated chloride ion channel activity
identical protein binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ion transport
signal transduction
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
negative regulation of synaptic transmission, GABAergic
ion transmembrane transport
neuron development
synaptic transmission, GABAergic
palate development
inhibitory postsynaptic potential
inner ear receptor cell development
innervation
cellular response to histamine
genetic imprinting
cochlea development
extrasynaptic signaling via GABA
chloride transmembrane transport
inhibitory synapse assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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