This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: ALKEKLGTPD EQLEMANCQA VILSVEDDTG HRIIIEDLLE ATRSPEVGMR QAAAIILNIY CSRSKADYTS HLRSLVSGLI RLFNDSSPVV LEESWDALNA ITKKLDAGNQ LALIEELHKE IRLIGNESKG EHVPGFC
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: eIF-2-alpha kinase activator GCN1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 eIF-2-alpha kinase activator homolog; GCN1 eIF2 alpha kinase activator homolog; GCN1 general control of amino-acid synthesis 1-like 1; GCN1-like protein 1; General control of amino-acid synthesis 1-like protein 1; HsGCN1; peroxisome proliferator activated receptor interacting complex protein; Translational activator GCN1
Gene Aliases: GCN1; GCN1L; GCN1L1; KIAA0219; PRIC295
UniProt ID: (Human) Q92616
Entrez Gene ID: (Human) 10985