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GRID2 Polyclonal Antibody
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Product Details
OSG00066W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 850-900 of human GRID2 conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: GRID2.
Target Information
GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: creeper; GluD2; gluR delta-2 subunit; glutamate receptor; glutamate receptor delta-2 subunit; Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; hotfoot; lurcher; minisatellite 10ac detected by probe MMS10; unnamed protein product
Gene Aliases:
B230104L07Rik; cpr; GluD2; GLURD2; GluRdelta2; GRID2; ho; Lc; Lc
UniProt ID: (Human) O43424, (Mouse) Q61625, (Rat) Q63226
Entrez Gene ID: (Human) 2895, (Mouse) 14804, (Rat) 79220
AMPA glutamate receptor activity
ion channel activity
protein binding
glutamate receptor activity
ligand-gated ion channel activity
PDZ domain binding
signaling receptor activity
identical protein binding
metal ion binding
scaffold protein binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
receptor activity
ionotropic glutamate receptor activity
extracellular-glutamate-gated ion channel activity
molecular_function
transmembrane signal receptor
ion transport
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
glutamate receptor signaling pathway
protein localization
regulation of neuron projection development
cerebellar granule cell differentiation
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of neuron apoptotic process
regulation of synaptic plasticity
modulation of synaptic transmission
regulation of synapse assembly
positive regulation of synapse assembly
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
prepulse inhibition
regulation of postsynaptic membrane neurotransmitter receptor levels
regulation of postsynaptic density assembly
synaptic signaling via neuropeptide
positive regulation of long term synaptic depression
excitatory synapse assembly
regulation of presynapse assembly
transport
cellular protein localization
biological_process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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