Antibodies that detect GRID2 can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, Immunohistochemistry (PFA fixed) and ELISA. These antibodies target GRID2 in Human, Rat and Mouse samples. Our GRID2 polyclonal and monoclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Relative expression to confirm specificity to GRID2. Find the GRID2 antibody that fits your needs. Choose from 1 of 6 GRID2 antibodies, which have been validated in experiments with 14 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.
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GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
GluD2; gluR delta-2 subunit; glutamate receptor; glutamate receptor delta-2 subunit; Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2
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