Immunohistochemical analysis of GRID2 in human skeletal muscle using GRID2 Polyclonal Antibody (Product # PA5-63274) shows no positivity in myocytes as expected.

GRID2 Antibody in Immunohistochemistry (IHC)

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GRID2 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of GRID2 demonstrates antibody specificity. Immunohistochemical analysis of GRID2 using anti-GRID2 Polyclonal Antibody (Product # PA5-63274), shows significant staining of GRID2 in human testis and shows minimal or weak staining in human endometrium tissues. The relative expression levels of GRID2 within each tissue is shown using RNA-Seq. {RE}

Immunogen image

Immunogen Image GRID2 Polyclonal Antibody

Product Details

PA5-63274

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human GRID2. Recombinant protein control fragment (Product #RP-91085).

3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

20 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2642216

Product Specific Information

Immunogen sequence: RVPSKEDDKE IDLEHLHRRV NSLCTDDDSP HKQFSTSSID LTPLDIDTLP TRQALEQISD FRNTHITTTT FIPEQIQTLS RTLSAKAASG FTFGNVPEHR TGPFRHRAPN GGFFRSPIKT MSSIPYQPTP TLGLNLGNDP DR

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Target Information

GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GluD2; gluR delta-2 subunit; glutamate receptor; glutamate receptor delta-2 subunit; Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; unnamed protein product

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Gene Aliases: GluD2; GLURD2; GRID2; SCAR18

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UniProt ID: (Human) O43424

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Entrez Gene ID: (Human) 2895

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Function(s)

AMPA glutamate receptor activity ion channel activity protein binding glutamate receptor activity ligand-gated ion channel activity PDZ domain binding signaling receptor activity identical protein binding metal ion binding scaffold protein binding transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Process(es)

ion transport heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules glutamate receptor signaling pathway protein localization regulation of neuron projection development cerebellar granule cell differentiation ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic regulation of neuron apoptotic process regulation of synaptic plasticity modulation of synaptic transmission regulation of synapse assembly positive regulation of synapse assembly regulation of postsynaptic membrane potential excitatory postsynaptic potential prepulse inhibition regulation of postsynaptic membrane neurotransmitter receptor levels regulation of postsynaptic density assembly synaptic signaling via neuropeptide positive regulation of long term synaptic depression excitatory synapse assembly regulation of presynapse assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GRID2 Polyclonal Antibody

GRID2 Antibody (PA5-63274) in IHC (P)

Product Details

PA5-63274

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Amount

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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