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GTP cyclohydrolase 1 Antibody (GTPCH1-112AP) in IHC
Mouse Spleen- GTP cyclohydrolase 1 Primary Antibody: GTPCH1-112AP; 1:100 dilution in IHC Blocking Buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification on Leica DM4000B microscope. FFPE section. Rabbit # 647.Pb3.AP.
Product Details
GTPCH1-112AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 25-75 on mouse GTPCHI protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP cyclohydrolase 1; GTP cyclohydrolase I; GTP-CH-I
Gene Aliases: Gch; Gch1; GTP-CH; GTPCH
UniProt ID: (Mouse) Q05915, (Rat) P22288
Entrez Gene ID: (Mouse) 14528, (Rat) 29244
protein complex assembly
tetrahydrobiopterin biosynthetic process
metabolic process
regulation of blood pressure
regulation of lung blood pressure
response to interferon-gamma
response to tumor necrosis factor
vasodilation
dopamine biosynthetic process
pteridine-containing compound biosynthetic process
negative regulation of blood pressure
tetrahydrofolate biosynthetic process
response to pain
neuromuscular process controlling posture
positive regulation of nitric-oxide synthase activity
dihydrobiopterin metabolic process
protein homooligomerization
protein heterooligomerization
response to lipopolysaccharide
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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