Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
dystonia 14; DYT14; DYT5; DYT5a; GCH; Gch1; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTPCH; GTP-CH; GTPCH1; GTP-CH-1; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I; HPABH4B
150 µL
100 µL
100 µL
100 µL
100 µL
100 µL
100 µL
100 µL
100 µg
100 µg
100 µg
100 µg
100 µg
100 µg
100 µg
100 µg
100 µg
100 µg
Searching for an antibody we don't offer? We make custom antibodies for specific targets, species and applications.
More than 18,000 custom antibodies created so far.
Talk to a specialist nowIf an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support