Invitrogen

GCH1 Polyclonal Antibody

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GCH1 Antibody in Western Blot (WB) — Western blot analysis of GCH1 in various samples (Lane 1: mouse heart, treated with blocking peptide, Lane 2: mouse heart, Lane 3: rat brain). Samples were incubated with GCH1 polyclonal antibody (Product # PA5-103865).

GCH1 Antibody in Western Blot (WB) — Western blot analysis of GCH1 in K562 cell lysate. Samples were incubated with GCH1 polyclonal antibody (Product # PA5-103865).

Product Details

PA5-103865

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000-1:3,000	-

Product Specifications
Species Reactivity	Rat, Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthesized peptide derived from human GCH1(Accession P30793), corresponding to amino acid residues S46-A73. View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.4, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C
RRID	AB_2853197

Target Information

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dystonia 14; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I

Gene Aliases: DYT14; DYT5; DYT5a; GCH; GCH1; GTP-CH; GTP-CH-1; GTPCH; GTPCH1; HPABH4B

UniProt ID: (Human) P30793, (Mouse) Q05915, (Rat) P22288

Entrez Gene ID: (Human) 2643, (Mouse) 14528, (Rat) 29244

Molecular Function: hydrolase metabolite interconversion enzyme

tetrahydrobiopterin biosynthetic process nitric oxide biosynthetic process regulation of blood pressure regulation of lung blood pressure response to lipopolysaccharide response to interferon-gamma response to tumor necrosis factor 7,8-dihydroneopterin 3'-triphosphate biosynthetic process vasodilation dopamine biosynthetic process pteridine-containing compound biosynthetic process negative regulation of blood pressure tetrahydrofolate biosynthetic process response to pain neuromuscular process controlling posture regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase activity protein homooligomerization protein heterooligomerization regulation of removal of superoxide radicals protein complex assembly metabolic process dihydrobiopterin metabolic process

Process(es)

GTP cyclohydrolase I activity calcium ion binding protein binding GTP binding zinc ion binding GTP-dependent protein binding protein homodimerization activity coenzyme binding nucleotide binding catalytic activity hydrolase activity metal ion binding