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Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dead end homolog 1; FLJ20491; HisRS; histidine translase; histidine tRNA ligase; Histidine--tRNA ligase, cytoplasmic; Histidyl-tRNA synthetase; histidyl-tRNA synthetase, cytoplasmic
Gene Aliases: CMT2W; Dnd1; HARS; HRS; MMHRS; USH3B
UniProt ID: (Human) P12081, (Mouse) Q61035
Entrez Gene ID: (Human) 3035, (Mouse) 15115, (Rat) 307492
Molecular Function:
RNA binding protein
aminoacyl-tRNA synthetase
ligase
nucleic acid binding
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