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Proteintech
HGS Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-10390
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HGS fusion protein Ag0589
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: GQIFCGKCS SKYSTIPKFG IEKEVRVCEP CYEQLNRKAE GKATSTTELP PEYLTSPLSQ QSQLPPKRDE TALQEEEELQ LALALSQSEA EEKERLRQKS TYTSYPKAEP MPSASSAPPA SSLYSSPVNS SAPLAEDIDP ELARYLNRNY WEKKQEEARK SPTPSAPVPL TEPAAQPGEG HAAPTNVVEN PLPETDSQPI PPS
Target Information
HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hepatocyte growth factor-regulated tyrosine kinase substrate; HGF-regulated tyrosine kinase substrate; HGNC:4897; Hrs; human growth factor-regulated tyrosine kinase substrate; Protein pp110; SNAP-25-interacting protein Hrs-2
Gene Aliases: Hgr; HGS; HRS; Hrs2; ZFYVE8
UniProt ID: (Human) O14964, (Rat) Q9JJ50, (Mouse) Q99LI8
Entrez Gene ID: (Human) 9146, (Rat) 56084, (Mouse) 15239
protein targeting to lysosome
autophagy
signal transduction
negative regulation of cell proliferation
membrane invagination
positive regulation of gene expression
endosomal transport
multivesicular body assembly
negative regulation of epidermal growth factor receptor signaling pathway
regulation of protein catabolic process
regulation of MAP kinase activity
negative regulation of JAK-STAT cascade
protein localization to membrane
positive regulation of exosomal secretion
endosome to lysosome transport
transport
intracellular protein transport
protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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