Hexokinases phosphorylate glucose to produce glucose 6 phosphate, thus committing glucose to the glycolytic pathway. In vertebrates there are four major glucose phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). Similar to hexokinases I and II, the allosteric enzyme hexokinase III is inhibited by its product glucose 6 phosphate. The catalytic activity of hexokinase III is associated with the C terminus while regulatory function is associated with the N terminus.
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Protein Aliases: ATP:D-hexose 6-phosphotransferase; hexokinase 3 (white cell); hexokinase iii; Hexokinase type III; Hexokinase-3; Hexokinase-C; Hexokinase3; HK III
Gene Aliases: HK III; HK-III; HK3; HKIII; HXK3; RNU73859