This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: GDFARFDPQG GLAGIAAIKA HLDILVERSN RSRAINVPPR VTVLPKSRVE
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 70%.
Reacts with HLA-DO, a heterodimer formed by DNalpha and DObeta subunits in B cells. DNalpha and DObeta are the products of the non-classical class II genes, HLA-DNA and HLA-DOB, respectively. DO forms tight complexes with DM in the endoplasmic reticulum and is thereby sorted to lysosomal vesicles during antigen processing and presentation. It is tightly associated with DM and it is selectively expressed on antigen-presenting cells, such as B cells, dendritic cells and thymic epithelial cells. DO can enhance the efficiency of peptide loading and has been found to stabilize DM at low pH, preserving its chaperon activity. DO-DM complexes are more efficient than DM in protecting empty DR molecules. Reports describe DO as a co-chaperone of DM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HLA class II histocompatibility antigen, DO alpha chain; HLA-D0-alpha; lymphocyte antigen; major histocompatibility complex, class II, DN alpha; MHC class II antigen DOA; MHC DN-alpha; MHC DZ alpha
Gene Aliases: HLA-DNA; HLA-DOA; HLA-DZA; HLADZ
UniProt ID: (Human) Q5STC7
Entrez Gene ID: (Human) 3111