Invitrogen

HMGA2 Polyclonal Antibody

View all (4) HMGA2 antibodies

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HMGA2 Antibody in Western Blot (WB) — Western blot analysis using a HMGA2 polyclonal antibody (Product # PA5-25276) in HepG2 cell lysates (35 µg per lane).

HMGA2 Antibody in Flow Cytometry (Flow) — Flow cytometry analysis of HepG2 cells using a HMGA2 polyclonal antibody (Product # PA5-25276) (right) compared to a negative control cell (left) at a dilution of 1:10-50, followed by a FITC-conjugated goat anti-rabbit antibody

Product Details

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1:10-1:50

-

Western Blot (WB)

1:1000

-

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human HMGA2

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2542776

Product Specific Information

This antibody is predicted to react with mouse based on sequence homology.

Target Information

HMGA2, previously known as HMGI-C, belongs to the group of high mobility chromosomal proteins that have the AT-hook DNA-binding motif. It is highly and ubiquitously expressed during embryogenesis. Chromosomal rearrangements of the HMGA2 gene and overexpression are frequently associated with benign and malignant tumors, respectively. Human and mouse HMGA2 shares 95% amino acid sequence identity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C

Gene Aliases: BABL; HMGA2; HMGI-C; HMGIC; LIPO; STQTL9

UniProt ID: (Human) P52926

Entrez Gene ID: (Human) 8091

Molecular Function: DNA binding protein nucleic acid binding

negative regulation of transcription from RNA polymerase II promoter epithelial to mesenchymal transition chondrocyte differentiation mesodermal-endodermal cell signaling base-excision repair chromatin organization regulation of transcription, DNA-templated transcription from RNA polymerase II promoter mitotic nuclear division mitotic G2 DNA damage checkpoint multicellular organism development response to virus regulation of cell cycle process positive regulation of gene expression chromosome condensation chromosome breakage heterochromatin assembly histone H2A-S139 phosphorylation senescence-associated heterochromatin focus assembly endodermal cell differentiation chondrocyte proliferation regulation of growth DNA damage response, detection of DNA damage positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of DNA binding negative regulation by host of viral transcription fat cell differentiation negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter mesodermal cell differentiation mesenchymal cell differentiation stem cell differentiation cell division positive regulation of cell cycle arrest oncogene-induced cell senescence regulation of stem cell population maintenance positive regulation of stem cell proliferation positive regulation of transcription regulatory region DNA binding positive regulation of cellular response to X-ray positive regulation of cellular senescence positive regulation of response to DNA damage stimulus negative regulation of double-strand break repair via nonhomologous end joining regulation of cellular response to drug

Process(es)

regulatory region DNA binding transcription factor activity, transcription factor binding core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding AT DNA binding DNA-(apurinic or apyrimidinic site) lyase activity DNA-dependent protein kinase activity protein binding transcription factor binding DNA binding, bending nucleosomal DNA binding cAMP response element binding MH2 domain binding MH1 domain binding SMAD binding 5'-deoxyribose-5-phosphate lyase activity C2H2 zinc finger domain binding