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Invitrogen
HMGA2 Polyclonal Antibody
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FIGURE: 1 / 6
HMGA2 Antibody (PA5-25276) in WB
Western blot was performed using Anti-HMGA2 Polyclonal Antibody (Product # PA5-25276) and a 18 kDa band corresponding to High mobility group protein HMGI-C was observed. Nuclear enriched extracts (30 µg lysate) of HCT 116 (Lane 1), SW480 (Lane 2), HT-29 (Lane 3), Hep G2 (Lane 4), ACHN (Lane 5), Caki-1 (Lane 6), A549 (Lane 7), A549 treated with 10 ng/mL TGF-B1 for 48 hrs (Lane 8) and NIH/3T3 (Lane 9) were electrophoresed using NuPAGE™ 12% Bis-Tris Protein Gel (Product # NP0342BOX). Resolved proteins were then transferred onto a Nitrocellulo... View More
Product Details
PA5-25276
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human HMGA2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
HMGA2, previously known as HMGI-C, belongs to the group of high mobility chromosomal proteins that have the AT-hook DNA-binding motif. It is highly and ubiquitously expressed during embryogenesis. Chromosomal rearrangements of the HMGA2 gene and overexpression are frequently associated with benign and malignant tumors, respectively. Human and mouse HMGA2 shares 95% amino acid sequence identity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: High mobility group AT-hook protein 2; High mobility group protein HMGI-C; HMGA2/KRT121P fusion; HMGI-C
Gene Aliases: BABL; HMGA2; HMGI-C; HMGIC; LIPO; SRS5; STQTL9
UniProt ID: (Human) P52926
Entrez Gene ID: (Human) 8091
transcription regulatory region sequence-specific DNA binding
nucleic acid binding
DNA binding
AT DNA binding
transcription cofactor activity
transcription corepressor activity
DNA-(apurinic or apyrimidinic site) lyase activity
protein binding
DNA binding, bending
enzyme binding
nucleosomal DNA binding
cAMP response element binding
MH2 domain binding
MH1 domain binding
SMAD binding
5'-deoxyribose-5-phosphate lyase activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
C2H2 zinc finger domain binding
negative regulation of transcription from RNA polymerase II promoter
epithelial to mesenchymal transition
chondrocyte differentiation
mesodermal-endodermal cell signaling
base-excision repair
chromatin organization
regulation of transcription, DNA-templated
spermatogenesis
cell proliferation
positive regulation of cell proliferation
male gonad development
response to virus
regulation of gene expression
positive regulation of macromolecule biosynthetic process
regulation of cell cycle process
positive regulation of gene expression
cell proliferation in forebrain
pituitary gland development
negative regulation of Wnt signaling pathway
chromosome condensation
adrenal gland development
heterochromatin assembly
negative regulation of intracellular steroid hormone receptor signaling pathway
somatic stem cell population maintenance
multicellular organism growth
intracellular signal transduction
endodermal cell differentiation
chondrocyte proliferation
positive regulation of multicellular organism growth
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
fat cell differentiation
positive regulation of angiogenesis
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
fibroblast proliferation
positive regulation of fibroblast proliferation
mesodermal cell differentiation
astrocyte differentiation
negative regulation of astrocyte differentiation
mesenchymal cell differentiation
stem cell differentiation
cell division
regulation of growth hormone secretion
lung epithelium development
epithelial tube branching involved in lung morphogenesis
positive regulation of epithelial cell proliferation involved in lung morphogenesis
adipose tissue development
fat pad development
positive regulation of cell proliferation in bone marrow
positive regulation of protein serine/threonine kinase activity
stem cell proliferation
regulation of peptide hormone secretion
oncogene-induced cell senescence
regulation of stem cell population maintenance
positive regulation of stem cell proliferation
negative regulation of cellular senescence
negative regulation of double-strand break repair via nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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