HMGA2, previously known as HMGI-C, belongs to the group of high mobility chromosomal proteins that have the AT-hook DNA-binding motif. It is highly and ubiquitously expressed during embryogenesis. Chromosomal rearrangements of the HMGA2 gene and overexpression are frequently associated with benign and malignant tumors, respectively. Human and mouse HMGA2 shares 95% amino acid sequence identity.
High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high mobility group protein I, isoform C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C; non-histone chromosomal architectural protein HMGI-C
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