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HMGA2/HMGI-C Polyclonal Antibody

View all (3) HMGA2 antibodies

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HMGA2/HMGI-C Polyclonal Antibody

Product Details

61041ACTMOTIF

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunoprecipitation (IP)

10 µL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This HMGA2 antibody was raised against a peptide within the N-terminal region of human HMGA2/HMGI-C.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Purification

Affinity chromatography

Storage buffer

70mM tris, pH 8, with 0.07mM EDTA, 30% glycerol, 31mM glycine, 105mM NaCl

Contains

0.035% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

HMGA2, previously known as HMGI-C, belongs to the group of high mobility chromosomal proteins that have the AT-hook DNA-binding motif. It is highly and ubiquitously expressed during embryogenesis. Chromosomal rearrangements of the HMGA2 gene and overexpression are frequently associated with benign and malignant tumors, respectively. Human and mouse HMGA2 shares 95% amino acid sequence identity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high mobility group protein I, isoform C; HMGA2/KRT121P fusion; HMGI-C

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Gene Aliases: 9430083A20Rik; BABL; HMGA2; HMGI-C; HMGIC; LIPO; pg; pygmy; SRS5; STQTL9

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UniProt ID: (Human) P52926, (Mouse) P52927

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Entrez Gene ID: (Human) 8091, (Mouse) 15364

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Function(s)
transcription regulatory region sequence-specific DNA binding nucleic acid binding DNA binding AT DNA binding transcription cofactor activity transcription corepressor activity DNA-(apurinic or apyrimidinic site) lyase activity protein binding DNA binding, bending enzyme binding nucleosomal DNA binding cAMP response element binding MH2 domain binding MH1 domain binding SMAD binding 5'-deoxyribose-5-phosphate lyase activity RNA polymerase II sequence-specific DNA binding transcription factor binding C2H2 zinc finger domain binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding endodeoxyribonuclease
Process(es)
negative regulation of transcription from RNA polymerase II promoter epithelial to mesenchymal transition chondrocyte differentiation mesodermal-endodermal cell signaling base-excision repair chromatin organization regulation of transcription, DNA-templated spermatogenesis cell proliferation positive regulation of cell proliferation male gonad development response to virus regulation of gene expression positive regulation of macromolecule biosynthetic process regulation of cell cycle process positive regulation of gene expression cell proliferation in forebrain pituitary gland development negative regulation of Wnt signaling pathway chromosome condensation adrenal gland development heterochromatin assembly negative regulation of intracellular steroid hormone receptor signaling pathway somatic stem cell population maintenance multicellular organism growth intracellular signal transduction endodermal cell differentiation chondrocyte proliferation positive regulation of multicellular organism growth negative regulation of apoptotic process negative regulation of DNA binding negative regulation by host of viral transcription fat cell differentiation positive regulation of angiogenesis negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade fibroblast proliferation positive regulation of fibroblast proliferation mesodermal cell differentiation astrocyte differentiation negative regulation of astrocyte differentiation mesenchymal cell differentiation stem cell differentiation cell division regulation of growth hormone secretion lung epithelium development epithelial tube branching involved in lung morphogenesis positive regulation of epithelial cell proliferation involved in lung morphogenesis adipose tissue development fat pad development positive regulation of cell proliferation in bone marrow positive regulation of protein serine/threonine kinase activity stem cell proliferation regulation of peptide hormone secretion oncogene-induced cell senescence regulation of stem cell population maintenance positive regulation of stem cell proliferation negative regulation of cellular senescence negative regulation of double-strand break repair via nonhomologous end joining transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle mitotic nuclear division signal transduction regulation of growth positive regulation of sequence-specific DNA binding transcription factor activity meiotic cell cycle nucleic acid phosphodiester bond hydrolysis
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