May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
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Protein Aliases: anti-death protein; cAMP inducible gene 3; DIF2; Differentiation-dependent gene 2 protein; expressed in pancreatic carcinoma; gly96, mouse, homolog of; IER3; IEX1; Immediate early protein GLY96; Immediate early response 3 protein; immediately early gene X-1; PACAP-responsive gene 1 protein; PRG1; Protein DIF-2; Protein PRG1; Radiation-inducible immediate-early gene IEX-1
Gene Aliases: AI663993; cI-3; DIF-2; DIF2; GLY96; IER3; IEX-1; IEX-1L; IEX1; PRG1
UniProt ID: (Human) P46695