Immunogen sequence: AHTGAARSCR FRGRHYKREF RLEGEPVALR CPQVPYWLWA SVSPRINLTW HKNDSARTVP GEEETRMWAQ DGALWLLPAL QEDSGTYVCT TRNASYCDKM SIELRVFENT DAFLPFISYP QILTLSTSGV LVCPDLSEFT RDKTDVKIQW YKDSLLLDKD NEKFLSVRGT THLLVHDVAL EDAGYYRCVL TFAHEGQQYN ITRSIELRIK KKKEETIPVI ISPLKTISAS LGSRLTIPCK VFLGTGTPLT TMLWWTANDT HIESAYPGGR VTEGPRQEYS ENNENYIEVP LIFDPVTRED L; Positive Samples: Raji, DU145, HeLa; Cellular Location: Cell membrane, Single-pass type I membrane protein
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.
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Protein Aliases: antigen CDw121b; CD121 antigen-like family member B; CD121b; CDw121b; IL-1 type II receptor; IL-1R-2; IL-1R-beta; ILR2; interleukin 1 receptor type II variant 3; interleukin 1 receptor, type II; Interleukin-1 receptor beta; Interleukin-1 receptor type 2; Interleukin-1 receptor type 2, membrane form; Interleukin-1 receptor type 2, soluble form; Interleukin-1 receptor type II; mIL-1R2; sIL-1R2; type II interleukin-1 receptor, beta
Gene Aliases: CD121b; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2; IL1R2; IL1R2c; IL1RB
UniProt ID: (Human) P27930
Entrez Gene ID: (Human) 7850