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IMPACT Polyclonal Antibody
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Product Details
BS-16625R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human IMPACT, amino acids 21-120.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMPACT; Impact homolog; Imprinted and ancient gene protein; Imprinted and ancient gene protein homolog; Protein IMPACT; RWD domain containing 5; unnamed protein product
Gene Aliases: E430016J11Rik; IMPACT; RWDD5
UniProt ID: (Human) Q9P2X3, (Mouse) O55091, (Rat) Q5GFD9
Entrez Gene ID: (Human) 55364, (Mouse) 16210, (Rat) 497198
negative regulation of transcription from RNA polymerase II promoter
regulation of translation
regulation of translational initiation
nervous system development
cell differentiation
cellular response to amino acid starvation
intracellular signal transduction
positive regulation of neuron differentiation
GCN2-mediated signaling
neuron projection extension
regulation of cytoplasmic translational initiation in response to stress
negative regulation of protein phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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