Invitrogen

IMPDH2 Polyclonal Antibody

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IMPDH2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of IMPDH2 in Hela cells using a IMPDH2 polyclonal antibody (Product # PA5-97886) at a dilution of 1:100. Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L) secondary antibody was used.

IMPDH2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of IMPDH2 in paraffin embedded human prostate cancer using a IMPDH2 polyclonal antibody (Product # PA5-97886) at a dilution of 1:100.

IMPDH2 Antibody in Western Blot (WB) — Western Blot analysis of IMPDH2 using a IMPDH2 Polyclonal antibody (Product # PA5-97886) at a concentration of 2 µg/mL. Lane 1: EC109 whole cell lysate. Lane 2: 293T whole cell lysate. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:15,000 dilution. Observed band size: 56 kDa.

Product Details

PA5-97886

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:50-1:200	-
ELISA (ELISA)	Assay-Dependent	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant Human Inosine-5'-monophosphate dehydrogenase 2 protein (5-514AA) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein G
Storage buffer	PBS, pH 7.4, with 50% glycerol
Contains	0.03% Proclin 300
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2812500

Target Information

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPDH 2; IMPDH II; IMPDH-II; IMPDH2; inosine 5' phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; Inosine-5'-monophosphate dehydrogenase 2

Gene Aliases: IMPD2; IMPDH-II; IMPDH2

UniProt ID: (Human) P12268

Entrez Gene ID: (Human) 3615

Molecular Function: dehydrogenase