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This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
HAMAP-Rule:MF_03156}; IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP dehydrogenase 2 {ECO:0000255; IMP dehydrogenase type II; IMP oxireductase 2; IMPD; IMPD 2; IMPD 2 {ECO:0000255; IMPD2; IMPDH 2; IMPDH 2 {ECO:0000255; IMPDH II; Impdh2; IMPDH-II; inosine 5' phosphate dehydrogenase 2; inosine 5-monophosphate dehydrogenase 2; inosine 5'-phosphate dehydrogenase 2; inosine monophosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; inosine-5'-monophosphate dehydrogenase 2; inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255
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