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This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
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Protein Aliases: IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMP dehydrogenase type II; IMP oxireductase 2; IMPD 2; IMPD 2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPDH 2; IMPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPDH II; IMPDH-II; IMPDH2; inosine 5' phosphate dehydrogenase 2; inosine 5'-phosphate dehydrogenase 2; inosine 5-monophosphate dehydrogenase 2; inosine monophosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; Inosine-5'-monophosphate dehydrogenase 2; inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}
Gene Aliases: IMPD; IMPD 2; IMPD2; IMPDH 2; IMPDH-II; IMPDH2
UniProt ID: (Human) P12268, (Mouse) P24547
Entrez Gene ID: (Human) 3615, (Rat) 301005, (Mouse) 23918
Molecular Function:
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
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