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Invitrogen
ING3 Polyclonal Antibody
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Product Details
PA5-102988
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ING3(Accession Q9NXR8), corresponding to amino acid residues V273-S323.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ING3.
Target Information
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Eaf 4; FLJ20089; ING 2; ING 3; Inhibitor of growth protein 3; p47 p47 ING3; p47 regulator protein; p47ING3; p47ING3 protein; unnamed protein product
Gene Aliases: 1300013A07Rik; Eaf4; HSPC301; ING2; ING3; MEAF4; P47ING3
UniProt ID: (Human) Q9NXR8, (Rat) Q498T3, (Mouse) Q8VEK6
Entrez Gene ID: (Human) 54556, (Rat) 312154, (Mouse) 71777
zinc ion binding
H4 histone acetyltransferase activity
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K12 specific)
H2A histone acetyltransferase activity
metal ion binding
histone acetyltransferase activity (H4-K16 specific)
histone H3K4me3 reader activity
molecular_function
histone acetyltransferase activity
methylated histone binding
chromatin/chromatin-binding, or -regulatory protein
chromatin organization
chromatin remodeling
regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
positive regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
biological_process
regulation of growth
positive regulation of apoptotic process
histone H4 acetylation
histone H2A acetylation
chromatin modification
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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