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Immunogen sequence: GMVKHITGSY KVTYHPDGPE GQAYDVDFTP PFRRINMVEE LEKALGMKLP ETNLFETEET RKILDDICVA KAVECPPPRT TARLLDKLVG EFLEVTCINP TFICDHPQIM SPLAKWHRSK
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 90%.
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: EC 126.96.36.199; lysine tRNA ligase; Lysine--tRNA ligase; LysRS; Lysyl-tRNA synthetase
Gene Aliases: AA589550; AL024334; AL033315; AL033367; CMTRIB; D8Ertd698e; D8Wsu108e; DFNB89; KARS; KARS1; KARS2; KIAA0070; KRS; LysRS; mKIAA0070
Molecular Function: aminoacyl-tRNA synthetase