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Abnova
KCNN4 Polyclonal Antibody, MaxPab™
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Product Details
H00003783-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KCNN4 (NP_002241.1, 1 a.a. approximately 427 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGGDLVLGLG ALRRRKRLLE QEKSLAGWAL VLAGTGIGLM VLHAEMLWFG GCSWALYLFL VKCTISISTF LLLCLIVAFH AKEVQLFMTD NGLRDWRVAL TGRQAAQIVL ELVVCGLHPA PVRGPPCVQD LGAPLTSPQP WPGFLGQGEA LLSLAMLLRL YLVPRAVLLR SGVLLNASYR SIGALNQVRF RHWFVAKLYM NTHPGRLLLG LTLGLWLTTA WVLSVAERQA VNATGHLSDT LWLIPITFLT IGYGDVVPGT MWGKIVCLCT GVMGVCCTAL LVAVVARKLE FNKAEKHVHN FMMDIQYTKE MKESAARVLQ EAWMFYKHTR RKESHAARRH QRKLLAAINA FRQVRLKHRK LREQVNSMVD ISKMHMILYD LQQNLSSSHR ALEKQIDTLA GKLDALTELL STALGPRQLP EPSQQSK
Target Information
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gardos channel; HIK1; hKCa4; IKCa; IKCa1; intermediate conductance calcium-activated potassium channel; Intermediate conductance calcium-activated potassium channel protein 4; intermediate-conductance Ca2+-activated K+ channel, KCa3.1; KCa3.1; KCNN 4; KCNN4; mIK1; mKCa4; Mutations: 960:OK; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; Putative Gardos channel; SK4; SKCa 4; SKCa4; small conductance calcium-activated potassium channel 4
Gene Aliases: DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; KCNN4; mIKCa1; SK4; SKCa4; SKCas
UniProt ID: (Human) O15554, (Mouse) O89109
Entrez Gene ID: (Human) 3783, (Mouse) 16534
potassium channel activity
protein binding
calmodulin binding
calcium-activated potassium channel activity
small conductance calcium-activated potassium channel activity
protein phosphatase binding
Intermediate conductance calcium-activated potassium channel activity
protein homodimerization activity
voltage-gated ion channel
immune system process
ion transport
potassium ion transport
calcium ion transport
cell volume homeostasis
defense response
stabilization of membrane potential
ion transmembrane transport
macropinocytosis
phospholipid translocation
saliva secretion
positive regulation of protein secretion
positive regulation of T cell receptor signaling pathway
regulation of transport
protein homotetramerization
establishment of localization in cell
regulation of biological quality
potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
regulation of calcium ion import across plasma membrane
transport
anion transport
potassium ion export
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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