Invitrogen

KCNN4 Polyclonal Antibody

6 Published Figures

5 References

View all (26) KCNN4 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)
Published Figures (6)

KCNN4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

KCNN4 Antibody (PA5-33875) in IHC (P)

Immunohistochemistry analysis of KCNN4 in human pancreas. Samples were incubated with KCNN4 polyclonal antibody (Product # PA5-33875). Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

KCNN4 Antibody in Immunohistochemistry (Frozen) (IHC (F))

KCNN4 Antibody in Immunohistochemistry (IHC)

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Product Details

PA5-33875

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

10 µg/mL

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Product Specifications

Species Reactivity

Bovine, Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 14 amino acid peptide from N-Terminus of human KCNN4.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.71 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2551244

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Bovine (100%) Marmoset, Panda, Dog, Rabbit, Pig (93%) Mouse, Rat, Guinea pig (86%).

Target Information

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Comparison of the Effect of Oral Versus Intravenous Bisphosphonate Administration on Osteoclastogenesis in Advanced-Stage Medication-Related Osteonecrosis of the Jaw Patients.

Journal of clinical medicine

Kim HW,Lee MW,Lee JH,Kim MY

Published figure using KCNN4 polyclonal antibody (Product # PA5-33875) in Immunohistochemistry

Sun Jul 04 00:00:00 UTC 2021

Comparison of the Effect of Oral Versus Intravenous Bisphosphonate Administration on Osteoclastogenesis in Advanced-Stage Medication-Related Osteonecrosis of the Jaw Patients.

Journal of clinical medicine

Kim HW,Lee MW,Lee JH,Kim MY

Published figure using KCNN4 polyclonal antibody (Product # PA5-33875) in Immunohistochemistry

Sun Jul 04 00:00:00 UTC 2021

Caveolae facilitate TRPV4-mediated Ca²⁺ signaling and the hierarchical activation of Ca²⁺-activated K⁺ channels in K⁺-secreting renal collecting duct cells.

American journal of physiology. Renal physiology

Li Y,Hu H,O'Neil RG

Published figure using KCNN4 polyclonal antibody (Product # PA5-33875) in Western Blot

Sat Dec 01 00:00:00 UTC 2018

Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney.

PloS one

Li Y,Hu H,Butterworth MB,Tian JB,Zhu MX,O'Neil RG

PA5-33875 was used in immunohistochemistry - frozen section and western blot to utilize the mechanosensitive TRPV4 channel in the collecting duct system of kidney that is coupled to expression of a diverse array of Ca2+-activated K+ channels (SK1/3, IK1,

Wed Jul 26 00:00:00 UTC 2017

Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney.

PloS one

Li Y,Hu H,Butterworth MB,Tian JB,Zhu MX,O'Neil RG

Wed Jul 26 00:00:00 UTC 2017

Human neuronal changes in brain edema and increased intracranial pressure.

Acta neuropathologica communications

Faragó N,Kocsis ÁK,Braskó C,Lovas S,Rózsa M,Baka J,Kovács B,Mikite K,Szemenyei V,Molnár G,Ozsvár A,Oláh G,Piszár I,Zvara Á,Patócs A,Barzó P,Puskás LG,Tamás G

Published figure using KCNN4 polyclonal antibody (Product # PA5-33875) in Immunofluorescence

Thu Aug 04 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Gardos channel; HIK1; hKCa4; IKCa; IKCa1; intermediate conductance calcium-activated potassium channel protein 1; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCNN 4; mIK1; mKCa4; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; Putative Gardos channel; SK4; SKCa 4; SKCa4; small conductance calcium-activated potassium channel 4

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Gene Aliases: DHS2; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; KCNN4; mIKCa1; SK4; SKCas

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UniProt ID: (Human) O15554, (Mouse) O89109

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Entrez Gene ID: (Human) 3783, (Bovine) 534591, (Mouse) 16534

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Function(s)

potassium channel activity protein binding calmodulin binding calcium-activated potassium channel activity small conductance calcium-activated potassium channel activity protein phosphatase binding Intermediate conductance calcium-activated potassium channel activity voltage-gated ion channel

Process(es)

immune system process potassium ion transport calcium ion transport anion transport cell volume homeostasis defense response stabilization of membrane potential phospholipid translocation saliva secretion positive regulation of protein secretion positive regulation of T cell receptor signaling pathway potassium ion export transport ion transport potassium ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KCNN4 Polyclonal Antibody

KCNN4 Antibody (PA5-33875) in IHC (P)

Product Details

PA5-33875

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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