Peptide sequence: DLQQNLSSSH RALEKQIDTL AGKLDALTEL LSTALGPRQL PEPSQQSK
Sequence homology: Cow: 92%; Horse: 92%; Human: 100%; Pig: 83%; Rat: 92%
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
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Protein Aliases: HIK1; IK1; IKCa; IKCa1; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCa4; KCNN 4; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; Putative Gardos channel; SK4; SKCa 4; SKCa4; small conductance calcium-activated potassium channel 4
Gene Aliases: DHS2; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; KCNN4; SK4
UniProt ID: (Human) O15554
Entrez Gene ID: (Human) 3783
Molecular Function: voltage-gated ion channel