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Proteintech
KMT2D Polyclonal Antibody
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Product Details
27266-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KMT2D Fusion Protein Ag26195 (4821-4920 aa encoded by NM_003482)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Amount
64.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MESPARAGT EPKKGEAEGP GGKEKGLEGK SPDTGPDWLK QFDAVLPGYT LKSQLDILSL LKQESPAPEP PTQHSYTYNV SNLDVRQLSA PPPEEPSPPP SP (4821-4920 aa encoded by N M_003482)
Target Information
KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription. KMT2D is involved in chromatin organization, chormatin silencig, oocyte growth, oogenesis, and a positive regulation of cell proliferation. Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1) which results in congential mental retardation syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AAD10; ALL1-related protein; alternatively spliced; similarity to ALL-1 and Drosophila trithorax; Histone-lysine N-methyltransferase 2D; histone-lysine N-methyltransferase MLL2; Kabuki make-up syndrome; lysine (K)-specific methyltransferase 2D; Lysine N-methyltransferase 2D; myeloid/lymphoid or mixed-lineage leukemia 2; Myeloid/lymphoid or mixed-lineage leukemia protein 2; trinucleotide repeat containing 21
Gene Aliases: AAD10; ALR; BCAHH; CAGL114; KABUK1; KMS; KMT2D; MLL2; MLL4; TNRC21
UniProt ID: (Human) O14686
Entrez Gene ID: (Human) 8085
transcription regulatory region sequence-specific DNA binding
DNA binding
transcription coactivator activity
protein binding
methyltransferase activity
zinc ion binding
transferase activity
histone methyltransferase activity (H3-K4 specific)
metal ion binding
histone H3K4 monomethyltransferase activity
histone H3K4 trimethyltransferase activity
oocyte growth
chromatin organization
regulation of transcription, DNA-templated
positive regulation of cell proliferation
heterochromatin assembly
methylation
positive regulation of intracellular estrogen receptor signaling pathway
response to estrogen
positive regulation of transcription from RNA polymerase II promoter
oogenesis
beta-catenin-TCF complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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