Antibodies that detect KMT2D can be used in several scientific applications, including Immunocytochemistry, Western Blot, Immunohistochemistry (PFA fixed), Immunohistochemistry (Paraffin) and Immunohistochemistry. These antibodies target KMT2D in Human samples. Our KMT2D polyclonal, recombinant monoclonal, recombinant polyclonal and monoclonal antibodies are developed in Rabbit and Mouse. Find the KMT2D antibody that fits your needs. Choose from 1 of 7 KMT2D antibodies, which have been validated in experiments with 18 images featured in our data gallery.
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KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription. KMT2D is involved in chromatin organization, chormatin silencig, oocyte growth, oogenesis, and a positive regulation of cell proliferation. Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1) which results in congential mental retardation syndrome.
ALL1-related protein; Histone-lysine N-methyltransferase 2D; histone-lysine N-methyltransferase MLL2; Kabuki make-up syndrome; Kabuki mental retardation syndrome; lysine (K)-specific methyltransferase 2D; Lysine N-methyltransferase 2D; myeloid/lymphoid or mixed-lineage leukemia 2; Myeloid/lymphoid or mixed-lineage leukemia protein 2; trinucleotide repeat containing 21
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