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Invitrogen
Ku70 Polyclonal Antibody
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Product Details
PA5-120056
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 408-609 of human Ku70 (NP_0014601)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
33 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: SKOV3, COS7, SW480, HeLa, Mouse brain, Mouse liver, Mouse skeletal muscle, Rat liver. The target is usually found in the following locations: Chromosome, Nucleus.
Immunogen sequence: PYFVALVPQE EELDDQKIQV TPPGFQLVFL PFADDKRKMP FTEKIMATPE QVGKMKAIVE KLRFTYRSDS FENPVLQQHF RNLEALALDL MEPEQAVDLT LPKVEAMNKR LGSLVDEFKE LVYPPDYNPE GKVTKRKHDN EGSGSKRPKV EYSEEELKTH ISKGTLGKFT VPMLKEACRA YGLKSGLKKQ ELLEALTKHF QD
Target Information
XRCC6 is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 5'-dRP/AP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CT; CTA-216E10.7; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein Ku70; DNA repair protein XRCC6; G22P1; Ku autoantigen p70 subunit; Ku autoantigen protein p70 homolog; Ku autoantigen, 70kDa; Ku p70; Ku protein subunit; Ku70; Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa); Lupus Ku autoantigen protein p70; OTTHUMP00000028581; p70 autoantigen; thyroid autoantigen; thyroid autoantigen 70 kDa; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6
Gene Aliases: 70kDa; CTC75; CTCBF; G22P1; KU70; Kup70; ML8; TLAA; XRCC6
UniProt ID: (Human) P12956, (Mouse) P23475
Entrez Gene ID: (Human) 2547, (Rat) 25019, (Mouse) 14375
nucleotide binding
transcription regulatory region sequence-specific DNA binding
DNA binding
DNA helicase activity
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
RNA binding
catalytic activity
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
hydrolase activity
lyase activity
ATPase activity
cyclin binding
telomeric DNA binding
macromolecular complex binding
DNA end binding
5'-deoxyribose-5-phosphate lyase activity
scaffold protein binding
ATP-dependent DNA helicase activity
protein C-terminus binding
transcription regulatory region DNA binding
poly(A) RNA binding
DNA helicase
telomere maintenance
recombinational repair
activation of innate immune response
immune system process
positive regulation of immune system process
DNA repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
response to ionizing radiation
negative regulation of macromolecule biosynthetic process
innate immune response
positive regulation of lymphocyte differentiation
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of smooth muscle cell proliferation
cellular hyperosmotic salinity response
cellular response to gamma radiation
cellular response to X-ray
double-strand break repair via classical nonhomologous end joining
double-strand break repair
brain development
DNA duplex unwinding
V(D)J recombination
positive regulation of neurogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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