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LSD1 Polyclonal Antibody

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LSD1 Polyclonal Antibody

Product Details

200-401-W52

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunoprecipitation (IP)

Assay-dependent
-

ChIP assay (ChIP)

3 µg
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-LSD1 Antibody was produced in rabbits by repeated immunizations with a full length recombinant protein of human LSD1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

50 µg

Purification

Protein G

Storage buffer

PBS, pH 7.2

Contains

0.05% ProClin 300, 0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A; amine oxidase (flavin containing) domain 2; BRAF35-HDAC complex protein BHC110; F9F13.30; F9F13_30; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; LESION SIMULATING DISEASE; LESION SIMULATING DISEASE 1; lysine (K)-specific demethylase 1A; lysine-specific histone demethylase 1; Lysine-specific histone demethylase 1A; RP1-184J9.1; unnamed protein product

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Gene Aliases: AIMAH3; AOF2; BHC110; CPRF; KDM1; KDM1A; KIAA0601; LSD1

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UniProt ID: (Human) Q96AW4

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Entrez Gene ID: (Human) 23028

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Function(s)
p53 binding chromatin binding transcription coactivator activity transcription corepressor activity RNA binding protein binding oxidoreductase activity enzyme binding histone demethylase activity histone demethylase activity (H3-K4 specific) histone demethylase activity (H3-K9 specific) telomeric DNA binding identical protein binding MRF binding flavin adenine dinucleotide binding androgen receptor binding RNA polymerase II sequence-specific DNA binding transcription factor binding telomeric repeat-containing RNA binding DNA-binding transcription factor binding protein demethylase activity FAD-dependent H3K4me/H3K4me3 demethylase activity promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter epithelial to mesenchymal transition positive regulation of neuroblast proliferation chromatin organization regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter regulation of double-strand break repair via homologous recombination positive regulation of epithelial to mesenchymal transition positive regulation of neuron projection development cerebral cortex development positive regulation of protein ubiquitination regulation of protein localization cellular response to UV protein modification process regulation of gene expression, epigenetic neuron maturation negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of cell differentiation positive regulation of cell size positive regulation of transcription from RNA polymerase II promoter guanine metabolic process regulation of neurogenesis positive regulation of multicellular organismal process muscle cell development regulation of androgen receptor signaling pathway response to fungicide cellular response to cAMP cellular response to gamma radiation positive regulation of cold-induced thermogenesis DNA repair-dependent chromatin remodeling negative regulation of transcription initiation-coupled chromatin remodeling negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation
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