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Invitrogen
C-Peptide Monoclonal Antibody (C-PEP-01), Biotin
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Product Details
MA1-10317
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
C-PEP-01
Immunogen
Human C-peptide conjugated to bovine serum albumin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts specifically with C-peptide, a part of the proinsulin molecule. Proinsulin consists of three parts: C-peptide and two long strands of amino acids (alpha and beta chains; later become linked together to form the insulin molecule). No cross-reactivity with insulin or other peptide hormones or proteins was observed.
Target Information
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cpeptide; INSU1; INSU2; INSU3B; INSUA; INSUB; INSUC; Insulin; insulin splice variant; insulin variant; INS-splice; preproinsulin; proinsulin
Gene Aliases: IDDM; IDDM1; IDDM2; ILPR; INS; IRDN; MODY10; PNDM4
UniProt ID: (Human) P01308
Entrez Gene ID: (Human) 3630
positive regulation of cytokine production
negative regulation of acute inflammatory response
glucose metabolic process
regulation of transcription, DNA-templated
acute-phase response
G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
insulin receptor signaling pathway
positive regulation of gene expression
negative regulation of gene expression
positive regulation of nitric oxide mediated signal transduction
positive regulation of neuron projection development
positive regulation of cell growth
positive regulation of cell migration
regulation of protein localization
nitric oxide-cGMP-mediated signaling pathway
TORC1 signaling
wound healing
negative regulation of protein catabolic process
vasodilation
glucose homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of cell differentiation
negative regulation of gluconeogenesis
positive regulation of glycogen biosynthetic process
positive regulation of translation
negative regulation of glycogen catabolic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
negative regulation of fatty acid metabolic process
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
alpha-beta T cell activation
positive regulation of lipid biosynthetic process
regulation of synaptic plasticity
regulation of protein secretion
negative regulation of protein secretion
positive regulation of protein secretion
cognition
negative regulation of lipid catabolic process
positive regulation of nitric-oxide synthase activity
positive regulation of protein kinase B signaling
fatty acid homeostasis
negative regulation of respiratory burst involved in inflammatory response
positive regulation of respiratory burst
positive regulation of peptide hormone secretion
positive regulation of brown fat cell differentiation
positive regulation of protein localization to nucleus
positive regulation of long-term synaptic potentiation
cellular response to oxygen-containing compound
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of dendritic spine maintenance
regulation of protein localization to plasma membrane
negative regulation of reactive oxygen species biosynthetic process
neuron projection maintenance
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of feeding behavior
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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