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HLA-G (soluble) Monoclonal Antibody (5A6G7), Biotin

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HLA-G (soluble) Monoclonal Antibody (5A6G7), Biotin

Product Details

MA1-10360

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

1-4 µg/mL
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5A6G7

Immunogen

C-terminal amino acid sequence (22-mer) of soluble HLA-G5 and HLA-G6 proteins coupled to ovalbumin.
3D Epitope / Immunogen

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11151937

Product Specific Information

This antibody was generated to a peptide corresponding to C-intron 4-encoded sequence. This antibody does not cross-react with the full-length HLA-G1 isoform and thus allows to distinguish between secreted HLA-G5 and HLA-G6 isoforms from shedded HLA-G1.

Target Information

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: b2 microglobulin; DADB-15K14.8; HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; HLA-G; HLA-G histocompatibility antigen, class I, G; HOSA-G1; MHC class I antigen G; MHC class I protein; MHC class Ib antigen; mutant MHC class I antigen; mutant MHC class Ib antigen; unnamed protein product

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Gene Aliases: HLA-6.0; HLA-G; HLAG; MHC-G

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UniProt ID: (Human) P17693

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Entrez Gene ID: (Human) 3135

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Function(s)
receptor binding protein binding peptide antigen binding CD8 receptor binding identical protein binding protein homodimerization activity
Process(es)
negative regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity immune system process peripheral B cell tolerance induction antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent positive regulation of tolerance induction positive regulation of T cell tolerance induction positive regulation of natural killer cell cytokine production immune response-inhibiting cell surface receptor signaling pathway immune response cellular defense response negative regulation of angiogenesis positive regulation of interleukin-12 production negative regulation of T cell proliferation protection from natural killer cell mediated cytotoxicity positive regulation of regulatory T cell differentiation negative regulation of natural killer cell mediated cytotoxicity negative regulation of immune response negative regulation of protein kinase B signaling positive regulation of macrophage cytokine production protein homotrimerization negative regulation of G0 to G1 transition positive regulation of endothelial cell apoptotic process positive regulation of cellular senescence negative regulation of dendritic cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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