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Invitrogen

CD40 Monoclonal Antibody (LOB7/6), PE

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Product Details

MA1-80928

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Neat
-
Product Specifications

Species Reactivity

Dog, Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

LOB7/6

Immunogen

CD40 Ig(Fc) fusion protein containing the EC region of human CD40 and Fc region of human IgG

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Lyophilized

Concentration

Conc. Not Determined

Purification

purified

Storage buffer

PBS, pH 7.4, with 5% sucrose, 1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_928285

Product Specific Information

Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4°C in the dark.

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

Mouse anti Human CD40 antibody, clone LOB7/6 recognizes the human CD40 cell surface antigen, a 48kDa glycoprotein expressed by B lymphocytes and weakly by some monocytes.

Target Information

CD40 is a single-chain glycoprotein and a member of the tumor necrosis factor receptor (TNFR) family, exhibiting significant homology to the Hodgkin's disease-associated antigen, CD30. It is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells, as well as some epithelial cells, carcinomas, and lymphoid dendritic cells. Notably, CD40 is present on all B cells except plasma cells. CD40 plays a crucial role in regulating B cell development and maturation, inducing immunoglobulin isotype-switching, and protecting B cells from surface Ig-induced apoptosis when combined with other signals such as IL-4. It promotes proliferation and is essential for T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction between CD40 and its ligand CD154 (gp39) on T cells is vital for T-B cell crosstalk, costimulation, and immune regulation. Adaptor protein TNFR2 interacts with CD40, mediating signal transduction, while the AT-hook transcription factor AKNA is reported to regulate CD40 expression, which may be important for homotypic cell interactions. Additionally, the interaction between CD40 and its ligand is necessary for amyloid-beta-induced microglial activation, suggesting a role in the early pathogenesis of Alzheimer's disease. Two alternatively spliced transcript variants encoding distinct isoforms of CD40 have been identified. Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency, highlighting its importance in immune and inflammatory responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

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Bioinformatics

Protein Aliases: B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; CD40; CD40 antigen (TNF receptor superfamily member 5); CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; Immunoglobulin M; ImmunoglobulinM; MGC9013; receptor for ligand CD154; sCD40; soluble CD40; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5

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Gene Aliases: Bp50; CD40; CDW40; p50; TNFRSF5

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UniProt ID: (Dog) Q7YRL5, (Human) P25942

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Entrez Gene ID: (Dog) 403469, (Human) 958

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Function(s)
signaling receptor activity antigen binding protein binding enzyme binding protein domain specific binding ubiquitin protein ligase binding transmembrane signal receptor
Process(es)
B cell activation regulation of immune response immune system process regulation of immunoglobulin production immune response-regulating cell surface receptor signaling pathway cellular calcium ion homeostasis defense response inflammatory response JAK-STAT cascade response to bacterium regulation of gene expression positive regulation of macromolecule biosynthetic process B cell mediated immunity CD40 signaling pathway platelet activation positive regulation of B cell proliferation response to nutrient levels positive regulation of interleukin-12 production response to cobalamin response to interferon-gamma cellular response to erythropoietin B cell proliferation defense response to protozoan positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade protein kinase B signaling positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes positive regulation of developmental process positive regulation of multicellular organismal process defense response to virus protein-containing complex assembly cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of protein kinase C signaling response to peptide positive regulation of interleukin-4-mediated signaling pathway positive regulation of endothelial cell apoptotic process
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