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Invitrogen
CD31 Monoclonal Antibody (LCI-4), Biotin
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Product Details
MA5-16770
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
LCI-4
Immunogen
Porcine CD31/human IgGFc fusion protein
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti Pig CD31, clone LCI-4 recognizes porcine CD31, also known as Platelet endothelial cell adhesion molecule (PECAM-1).
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion molecule; CD31 antigen; PECAM-1 precursor; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); type I transmembrane endothelial adhesion molecule; unnamed protein product
Gene Aliases: CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; PECAM-1
UniProt ID: (Pig) Q95242, (Human) P16284
Entrez Gene ID: (Pig) 396941, (Human) 5175
blood vessel development
endothelial cell development
phagocytosis
immune response
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
leukocyte cell-cell adhesion
signal transduction
cell surface receptor signaling pathway
cell recognition
cell migration
regulation of cell migration
positive regulation of cell migration
maintenance of blood-brain barrier
monocyte extravasation
T cell activation
vasodilation
positive regulation of MAPK cascade
diapedesis
detection of mechanical stimulus
positive regulation of protein kinase B signaling
establishment of endothelial barrier
bicellular tight junction assembly
cellular response to mechanical stimulus
glomerular endothelium development
neutrophil extravasation
cell-cell adhesion
positive regulation of protein localization to cell-cell junction
positive regulation of intracellular signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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