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Invitrogen
CD31 (PECAM-1) Monoclonal Antibody (LCI-4)
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FIGURE: 1 / 1
CD31 (PECAM-1) Antibody (MA5-28345) in Flow
Flow cytometry of CD31 (PECAM-1) in red cell lysed porcine blood. Sample was incubated with CD31 (PECAM-1) monoclonal antibody (Product # MA5-28345) and gated on mononuclear cells. Figures are arranged as follows: A) Alexa Fluor 647 conjugated Mouse anti Porcine CD45 and FITC conjugated Mouse IgG1 isotype control. B) Alexa Fluor 647 conjugated Mouse anti Porcine CD45 and FITC conjugated Mouse anti Porcine CD31.
Product Details
MA5-28345
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
LCI-4
Immunogen
Porcine CD31/human IgGFc fusion protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes porcine CD31, also known as Platelet endothelial cell adhesion molecule (PECAM-1). CD31 is constitutively expressed by platelets, monocytes and some lymphocytes, it is expressed by endothelial cells at a level, an order of magnitude greater that of other cell types.
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD31; PECAM-1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule (CD31 antigen); type I transmembrane endothelial adhesion molecule
Gene Aliases: CD31; PECAM-1; PECAM1
UniProt ID: (Pig) Q95242
Entrez Gene ID: (Pig) 396941
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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