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Invitrogen

NLGN3 Monoclonal Antibody (N110/29)

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NLGN3 Monoclonal Antibody (N110/29)

Product Details

MA5-27621

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:100
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N110/29

Immunogen

Fusion protein amino acids 730-848 (intracellular C-terminus) of rat Neuroligin-3. Mouse: 99% identity (118/119 amino acids identical). Human: 98% identity (116/119 amino acids identical) ~60% identity with Neuroligin-1. ~40% identity with Neuroligin-2.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735291

Product Specific Information

1 µg/mL of MA5-27621 was sufficient for detection of Neuroligin 3 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 110kDa. Does not cross-react with Neuroligin-1, -2, -4 or -4.

This antibody was formerly sold as clone S110-29.

Target Information

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ASPGX1; AUTSX1; Gliotactin homolog; neuroligin 3 protein; Neuroligin-3; unnamed protein product

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Gene Aliases: A230085M13Rik; HNL3; KIAA1480; NL3; NLGN3

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UniProt ID: (Human) Q9NZ94, (Mouse) Q8BYM5, (Rat) Q62889

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Entrez Gene ID: (Human) 54413, (Mouse) 245537, (Rat) 171297

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Function(s)
protein binding signaling receptor activity neurexin family protein binding cell adhesion molecule binding scaffold protein binding receptor activity carboxylic ester hydrolase activity cell adhesion molecule
Process(es)
regulation of respiratory gaseous exchange by neurological system process receptor-mediated endocytosis cell adhesion neuron cell-cell adhesion chemical synaptic transmission synapse assembly learning adult behavior social behavior synaptic vesicle endocytosis axon extension modulation of synaptic transmission synapse organization positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic rhythmic synaptic transmission inhibitory postsynaptic potential vocalization behavior postsynaptic membrane assembly presynaptic membrane assembly presynapse assembly positive regulation of glutamate receptor signaling pathway positive regulation of excitatory postsynaptic potential visual learning oligodendrocyte differentiation regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential positive regulation of dendritic spine development regulation of dendritic spine morphogenesis positive regulation of inhibitory postsynaptic potential regulation of long-term synaptic potentiation positive regulation of protein localization to synapse regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity regulation of terminal button organization positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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