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Invitrogen
CaV3.2 Monoclonal Antibody (N55/10)
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FIGURE: 1 / 2
CaV3.2 Antibody (MA5-27656) in IHC (P)
Immunohistochemistry analysis of CaV3.2 in paraffin-embedded human hippocampus. Samples were prepared with Bouin's fixative solution, incubated with CaV3.2 monoclonal antibody (Product # MA5-27656) using a dilution of 1:1000 (1 hour at RT) and followed by FITC Goat Anti-Mouse (green) at a dilution of 1:50 (1 hour at RT).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-27656
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N55/10
Immunogen
Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
1 µg/mL of MA5-27656 was sufficient for detection of Cav3.2 in 10 µg of HEK cell lysate expressing Cav3.2 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 260kDa. No cross-reactivity against Cav1.3.
Target Information
This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A1H-b; calcium channel alpha13.2 subunit; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; domain I; FLJ90484; low voltage-activated; alpha 1H; low voltage-activated; CavT.2; low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; T-type Cav3.2; unnamed protein product; voltage dependent t-type calcium channel alpha-1H subunit; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; voltage-gated calcium channel subunit alpha Cav3.2
Gene Aliases: alpha13.2; CACNA1HB; Cav3.2; ECA6; EIG6; HALD4; MNCb-1209
UniProt ID: (Human) O95180, (Rat) Q9EQ60
Entrez Gene ID: (Human) 8912, (Rat) 114862, (Mouse) 58226
ion transport
muscle contraction
muscle organ development
myoblast fusion
regulation of heart contraction
aldosterone biosynthetic process
cellular response to hormone stimulus
cortisol biosynthetic process
cellular response to potassium ion
regulation of membrane potential
transmembrane transport
calcium ion import
calcium ion transmembrane transport
calcium ion import across plasma membrane
positive regulation of acrosome reaction
calcium ion transport
sodium ion transmembrane transport
positive regulation of calcium ion-dependent exocytosis
membrane depolarization during action potential
positive regulation of cardiac muscle cell contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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