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Invitrogen
CD11b Monoclonal Antibody (CC126)
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FIGURE: 1 / 1
CD11b Antibody (MA5-28275) in Flow
Flow cytometry of CD11b in red cell lysed bovine blood. Sample was incubated in the presence of 10% bovine serum, CD11b monoclonal antibody (Product # MA5-28275) and gated on live cells. Figures are arranged as follows: A) RPE conjugated Mouse anti Bovine CD335 and FITC conjugated Mouse IgG2b isotype control. B) RPE conjugated Mouse anti Bovine CD335 and FITC conjugated Mouse anti Bovine CD11b.
Product Details
MA5-28275
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
CC126
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Mouse anti Bovine CD11b antibody, clone CC126 recognizes the bovine CD11b cell surface antigen.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen CD11b (p170); macrophage antigen alpha polypeptide; integrin alpha M; integrin, alpha M (complement component 3 receptor 3 subunit); leukocyte integrin alpha-M chain; Mac-1 alpha (Mac1A); MGC117044
Gene Aliases: CD11B
Entrez Gene ID: (Bovine) 407124
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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