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Invitrogen

ICAM-1 Recombinant Rabbit Monoclonal Antibody (037)

1 Published Figure
1 Reference
View all (151) ICAM-1 (CD54) antibodies

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ICAM-1 Recombinant Rabbit Monoclonal Antibody (037)

Product Details

MA5-29866

Applications
Tested Dilution
Publications

Western Blot (WB)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:20-1:100
-

Flow Cytometry (Flow)

1:25-1:100
-
Product Specifications

Species Reactivity

Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

037

Immunogen

Recombinant Rat ICAM-1/CD54 protein (Met1-Thr493)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2785683

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This antibody has specificity for Rat ICAM-1/CD54.

Target Information

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Human rhinovirus receptor; ICAM-1; Ly 47; MALA2; sCD54; soluble CD54; Surface antigen of activated B cells

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Gene Aliases: CD54; ICAM; RICAM-I

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UniProt ID: (Rat) Q00238

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Entrez Gene ID: (Rat) 25464

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Function(s)
integrin binding macromolecular complex binding receptor agonist activity
Process(es)
ovarian follicle development response to hypoxia response to amphetamine T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell acute inflammatory response to antigenic stimulus T cell antigen processing and presentation positive regulation of cellular extravasation immune response cell adhesion leukocyte cell-cell adhesion I-kappaB kinase/NF-kappaB signaling regulation of cell shape response to xenobiotic stimulus response to ionizing radiation response to sulfur dioxide membrane to membrane docking positive regulation of actin filament polymerization cellular response to nutrient levels response to lipopolysaccharide response to insulin cell adhesion mediated by integrin cell-cell adhesion mediated by integrin response to gonadotropin response to amino acid positive regulation of GTPase activity positive regulation of nitric oxide biosynthetic process response to ethanol positive regulation of vasoconstriction regulation of activated T cell proliferation response to copper ion positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration negative regulation of calcium ion transport establishment of endothelial barrier leukocyte adhesion to vascular endothelial cell positive regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to alkaloid cellular response to glucose stimulus cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to hypoxia cellular response to dexamethasone stimulus T cell extravasation cellular senescence establishment of endothelial intestinal barrier establishment of Sertoli cell barrier cell-cell adhesion regulation of ruffle assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine cellular response to beta-amyloid positive regulation of leukocyte adhesion to vascular endothelial cell cellular response to leukemia inhibitory factor negative regulation of endothelial cell apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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