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ICAM-1 Recombinant Rabbit Monoclonal Antibody (037), APC

View all (130) ICAM-1 (CD54) antibodies

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ICAM-1 Recombinant Rabbit Monoclonal Antibody (037), APC

Product Details

MA5-46870

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

10 µL/test
-
Product Specifications

Species Reactivity

Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

037

Immunogen

Recombinant protein encoding Rat ICAM-1 (Met1-Thr493).
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

100 µg/mL

Purification

Protein A

Storage buffer

PBS with 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2937942

Product Specific Information

Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Rat ICAM-1 (CD54) (Met1-Thr493) and conjugated with APC under optimum conditions, the unreacted APC was removed.

Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Target Information

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Human rhinovirus receptor; ICAM-1; Ly 47; MALA2; sCD54; soluble CD54; Surface antigen of activated B cells

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Gene Aliases: CD54; ICAM; RICAM-I

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UniProt ID: (Rat) Q00238

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Entrez Gene ID: (Rat) 25464

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Function(s)
integrin binding macromolecular complex binding receptor agonist activity
Process(es)
ovarian follicle development response to hypoxia response to amphetamine T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell acute inflammatory response to antigenic stimulus T cell antigen processing and presentation positive regulation of cellular extravasation immune response cell adhesion leukocyte cell-cell adhesion I-kappaB kinase/NF-kappaB signaling regulation of cell shape response to xenobiotic stimulus response to ionizing radiation response to sulfur dioxide membrane to membrane docking positive regulation of actin filament polymerization cellular response to nutrient levels response to lipopolysaccharide response to insulin cell adhesion mediated by integrin cell-cell adhesion mediated by integrin response to gonadotropin response to amino acid positive regulation of GTPase activity positive regulation of nitric oxide biosynthetic process response to ethanol positive regulation of vasoconstriction regulation of activated T cell proliferation response to copper ion positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration negative regulation of calcium ion transport establishment of endothelial barrier leukocyte adhesion to vascular endothelial cell positive regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to alkaloid cellular response to glucose stimulus cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to hypoxia cellular response to dexamethasone stimulus T cell extravasation cellular senescence establishment of endothelial intestinal barrier establishment of Sertoli cell barrier cell-cell adhesion regulation of ruffle assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine cellular response to beta-amyloid positive regulation of leukocyte adhesion to vascular endothelial cell cellular response to leukemia inhibitory factor negative regulation of endothelial cell apoptotic process
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