Search
Invitrogen
SOX10 Recombinant Rabbit Monoclonal Antibody (SN20-41)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 8
SOX10 Antibody (MA5-32335) in IHC (P)
Immunohistochemical analysis of SOX10 was performed using formalin-fixed paraffin-embedded human skin (Malignant melanoma) tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius ... View More
Product Details
MA5-32335
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SN20-41
Immunogen
Synthetic peptide within Human SOX10 aa 400-450.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: dominant megacolon; dominant megacolon, mouse, human homolog of; MGC15649; Protein SOX-21; SOX10; SRY; SRY (sex determining region Y)-box 10; SRY-box 10; SRY-box containing gene 10; SRY-related HMG-box gene 10; Transcription factor SOX-10; Transcription factor SOX-M; unnamed protein product
Gene Aliases: DOM; PCWH; SOX-10; SOX10; Sox21; WS2E; WS4; WS4C
UniProt ID: (Human) P56693, (Rat) O55170, (Mouse) Q04888
Entrez Gene ID: (Human) 6663, (Rat) 29361, (Mouse) 20665
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor binding
transcription regulatory region DNA binding
in utero embryonic development
neural crest cell migration
positive regulation of neuroblast proliferation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
peripheral nervous system development
positive regulation of gliogenesis
cell differentiation
melanocyte differentiation
lacrimal gland development
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
cell maturation
enteric nervous system development
digestive tract morphogenesis
developmental growth
oligodendrocyte differentiation
stem cell differentiation
morphogenesis of a branching epithelium
negative regulation of canonical Wnt signaling pathway
transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
morphogenesis of an epithelium
regulation of transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
neuroblast proliferation
anatomical structure morphogenesis
negative regulation of Schwann cell proliferation
positive regulation of gene expression
oligodendrocyte development
central nervous system myelination
positive regulation of myelination
developmental process
cellular response to progesterone stimulus
cellular response to xenobiotic stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support