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Invitrogen

Phospho-ZAP70/Syk (Tyr319, Tyr352) Recombinant Rabbit Monoclonal Antibody (Zap70Y319-A3), PE

View all (11) ZAP70/Syk antibodies

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Product Details

MA5-36962

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µL/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

Zap70Y319-A3

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Tyr319/Tyr352 of human phospho Zap70/Syk.

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.20% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2896897

Target Information

ZAP70 and SYK are closely related cytoplasmic tyrosine kinases that play central roles in immune receptor signaling. ZAP70 (Zeta-chain-associated protein kinase 70; gene: ZAP70) is primarily expressed in T lymphocytes and natural killer (NK) cells, where it is recruited to the T cell receptor (TCR) complex following antigen recognition. Upon activation, ZAP70 phosphorylates downstream adaptor proteins and initiates signaling cascades that drive T cell activation, proliferation, and differentiation. SYK (Spleen Tyrosine Kinase; gene: SYK) is predominantly expressed in B cells and other hematopoietic cells and functions analogously in B cell receptor (BCR) signaling, as well as in Fc receptor and integrin-mediated pathways. Although ZAP70 and SYK share structural homology and overlapping signaling mechanisms, they exhibit distinct expression patterns and immunological roles. Dysregulation of either kinase has been implicated in autoimmune disease, immunodeficiency, and hematologic malignancies, making them important targets in immunology and therapeutic research.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; p72-Syk; Spleen tyrosine kinase; Syk kinase; Syk-related kinase; Syk-related tyrosine kinase; TCR-associated protein tyrosine kinase; Tyrosine-protein kinase SYK; Tyrosine-protein kinase ZAP-70; ZAP-70

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Gene Aliases: mrtle; mur; ptk72; SRK; SYK; Sykb; ZAP-70; ZAP70

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UniProt ID: (Mouse) P48025, (Mouse) P43404

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Entrez Gene ID: (Mouse) 20963, (Mouse) 22637

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity receptor binding integrin binding protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein kinase binding protein domain specific binding phosphotyrosine binding kinase modulator
Process(es)
activation of MAPK activity angiogenesis serotonin secretion lymph vessel development adaptive immune response macrophage activation involved in immune response neutrophil activation involved in immune response leukocyte activation involved in immune response immune system process serotonin secretion by platelet protein phosphorylation leukocyte cell-cell adhesion cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway integrin-mediated signaling pathway activation of JUN kinase activity regulation of platelet activation regulation of tumor necrosis factor-mediated signaling pathway phosphorylation cell migration peptidyl-serine phosphorylation peptidyl-tyrosine phosphorylation leukotriene biosynthetic process signal transduction by protein phosphorylation cell differentiation neutrophil chemotaxis regulation of superoxide anion generation positive regulation of cell adhesion mediated by integrin intracellular signal transduction peptidyl-tyrosine autophosphorylation defense response to bacterium transcription factor import into nucleus positive regulation of mast cell degranulation regulation of neutrophil degranulation beta selection innate immune response positive regulation of interleukin-3 biosynthetic process positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of bone resorption positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation protein autophosphorylation blood vessel morphogenesis positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation regulation of phagocytosis regulation of immune response positive regulation of calcium-mediated signaling B cell receptor signaling pathway regulation of sequence-specific DNA binding transcription factor activity regulation of ERK1 and ERK2 cascade cellular response to molecule of fungal origin regulation of arachidonic acid secretion regulation of platelet aggregation immune response positive thymic T cell selection negative thymic T cell selection thymic T cell selection positive regulation of T cell differentiation T cell receptor signaling pathway
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