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Invitrogen

Phospho-ZAP70/Syk (Tyr319, Tyr352) Recombinant Rabbit Monoclonal Antibody (Zap70Y319-A3), PE

View all (11) ZAP70/Syk antibodies

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Product Details

MA5-36962

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µL/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

Zap70Y319-A3

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Tyr319/Tyr352 of human phospho Zap70/Syk.

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.20% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2896897

Target Information

ZAP70 and SYK are closely related cytoplasmic tyrosine kinases that play central roles in immune receptor signaling. ZAP70 (Zeta-chain-associated protein kinase 70; gene: ZAP70) is primarily expressed in T lymphocytes and natural killer (NK) cells, where it is recruited to the T cell receptor (TCR) complex following antigen recognition. Upon activation, ZAP70 phosphorylates downstream adaptor proteins and initiates signaling cascades that drive T cell activation, proliferation, and differentiation. SYK (Spleen Tyrosine Kinase; gene: SYK) is predominantly expressed in B cells and other hematopoietic cells and functions analogously in B cell receptor (BCR) signaling, as well as in Fc receptor and integrin-mediated pathways. Although ZAP70 and SYK share structural homology and overlapping signaling mechanisms, they exhibit distinct expression patterns and immunological roles. Dysregulation of either kinase has been implicated in autoimmune disease, immunodeficiency, and hematologic malignancies, making them important targets in immunology and therapeutic research.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; spleen tyrosine kinase; Syk kinase; Syk-related kinase; syk-related tyrosine kinase; TCR-associated protein tyrosine kinase; unnamed protein product; ZAP-70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD

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Gene Aliases: ADMIO2; IMD48; IMD82; mrtle; mur; p72-Syk; SRK; STCD; STD; Sykb; TZK; ZAP-70

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UniProt ID: (Human) P43405, (Mouse) P48025, (Human) P43403, (Mouse) P43404

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Entrez Gene ID: (Human) 6850, (Mouse) 20963, (Human) 7535, (Mouse) 22637

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Function(s)
phosphotyrosine binding protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding integrin binding protein binding ATP binding interleukin-15 receptor binding kinase activity protein kinase binding phosphatase binding Toll-like receptor binding SH2 domain binding phospholipase binding scaffold protein binding protein domain specific binding ubiquitin protein ligase binding immunoglobulin receptor binding
Process(es)
cell activation lymph vessel development positive regulation of receptor internalization stimulatory C-type lectin receptor signaling pathway adaptive immune response macrophage activation involved in immune response neutrophil activation involved in immune response leukocyte activation involved in immune response serotonin secretion by platelet cell surface pattern recognition receptor signaling pathway negative regulation of inflammatory response to antigenic stimulus regulation of transcription from RNA polymerase II promoter protein phosphorylation protein import into nucleus leukocyte cell-cell adhesion integrin-mediated signaling pathway organ morphogenesis regulation of platelet activation regulation of tumor necrosis factor-mediated signaling pathway peptidyl-tyrosine phosphorylation platelet activation neutrophil chemotaxis positive regulation of protein complex assembly receptor internalization positive regulation of type I interferon production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production regulation of superoxide anion generation positive regulation of superoxide anion generation positive regulation of cell adhesion mediated by integrin positive regulation of toll-like receptor 9 signaling pathway intracellular signal transduction Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis interleukin-3-mediated signaling pathway defense response to bacterium regulation of neutrophil degranulation innate immune response positive regulation of B cell differentiation positive regulation of lymphocyte differentiation positive regulation of bone resorption blood vessel morphogenesis positive regulation of inflammatory response regulation of phagocytosis regulation of immune response B cell receptor signaling pathway leukocyte migration regulation of ERK1 and ERK2 cascade cellular response to molecule of fungal origin cellular response to lipid cellular response to low-density lipoprotein particle stimulus positive regulation of monocyte chemotactic protein-1 production regulation of arachidonic acid secretion regulation of platelet aggregation apoptotic signaling pathway beta-amyloid clearance positive regulation of cold-induced thermogenesis positive regulation of cGAS/STING signaling pathway positive regulation of TORC1 signaling cellular response to beta-amyloid cellular response to lectin autophagosome assembly positive regulation of cytokine production serotonin secretion cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway G-protein coupled receptor signaling pathway negative regulation of autophagy positive regulation of autophagy peptidyl-serine phosphorylation leukotriene biosynthetic process cellular response to nutrient levels positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interleukin-3 production collagen-activated tyrosine kinase receptor signaling pathway TORC1 signaling positive regulation of mast cell degranulation beta selection positive regulation of MAPK cascade positive regulation of JUN kinase activity positive regulation of gamma-delta T cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation protein autophosphorylation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling antigen receptor-mediated signaling pathway negative regulation of TORC1 signaling immune response T cell activation positive thymic T cell selection negative thymic T cell selection thymic T cell selection positive regulation of T cell differentiation T cell receptor signaling pathway T cell differentiation B cell activation T cell aggregation T cell migration
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