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Invitrogen
Phospho-MKK7 (Ser271, Thr275) Recombinant Rabbit Monoclonal Antibody (MKK7S271T275-R4F9), APC
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FIGURE: 1 / 1
Phospho-MKK7 (Ser271, Thr275) Antibody (MA5-37008) in Flow
Flow cytometry of Phospho-MKK7 (Ser271, Thr275) using 293T cells. Samples were incubated in monoclonal Phospho-MKK7 (Ser271, Thr275) antibody (Product # MA5-37008). Images correspond with the following conditions: unstained treated with imatinib as negative control (blue) or treated with imatinib (red) or treated with UV plus TPA.
Product Details
MA5-37008
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MKK7S271T275-R4F9
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser271 and Thr275 of human MKK7.
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a new family member of MAP kinase kinases; c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JN; JNK kinase 2; JNK-activating kinase 2; MAP kinase kinase 7; MAP2K4; MAPK/ERK kinase 4; MAPK/ERK kinase 7; MAPKK 4; MEK 4; MEK 7; protein kinase; protein kinase homolog; SAPK kinase 1; SAPK kinase 4; SAPK/ERK kinase 1; SAPKK-1; SAPKK1; SEK1; Stress-activated protein kinase kinase 4; unnamed protein product
Gene Aliases: JNKK2; MAP2K7; MAPKK7; MEK; MEK 7; MEK7; MKK7; PRKMK7; SAPKK-4; SAPKK4; SKK4
UniProt ID: (Human) O14733
Entrez Gene ID: (Human) 5609
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
JUN kinase kinase activity
kinase activity
transferase activity
enzyme binding
protein kinase binding
protein phosphatase binding
metal ion binding
protein serine kinase activity
molecular function activator activity
apoptotic process
response to osmotic stress
signal transduction
JNK cascade
response to heat
response to UV
response to wounding
stress-activated protein kinase signaling cascade
positive regulation of telomere maintenance
response to tumor necrosis factor
Fc-epsilon receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
stress-activated MAPK cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular senescence
regulation of motor neuron apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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