Search
Invitrogen
Phospho-MAPKAPK2 (Thr334) Recombinant Rabbit Monoclonal Antibody (MAPKAPK2T334-H2)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 4
Phospho-MAPKAPK2 (Thr334) Antibody (MA5-37010) in WB
Western blot analysis of Phospho-MAPKAPK2 (Thr334) using HeLa cell extract. Samples were untreated or treated with UV and TPA, and incubated in monoclonal Phospho-MAPKAPK2 (Thr334) antibody (Product # MA5-37010) with a dilution of 0.05 µg/mL.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-37010
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MAPKAPK2T334-H2
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr334 of human phospho MAPKAPK-2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
10 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation. MAPKAPK2 encodes a member of the Ser/Thr protein kinase family. MAPKAPK2 is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, MAPKAPK2 is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for MAPKAPK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: MAPK-activated protein kinase 2; MAPKAP kinase 2; mitogen-activated protein kinase-activated protein kinase 2
Gene Aliases: MAPKAP-K2; MK-2; MK2; Rps6kc1
UniProt ID: (Human) P49137, (Mouse) P49138
Entrez Gene ID: (Human) 9261, (Mouse) 17164
MAPK cascade
toll-like receptor signaling pathway
leukotriene metabolic process
inflammatory response
cellular response to DNA damage stimulus
regulation of tumor necrosis factor-mediated signaling pathway
response to lipopolysaccharide
regulation of interleukin-6 production
regulation of tumor necrosis factor production
response to cytokine
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
regulation of mRNA stability
macropinocytosis
vascular endothelial growth factor receptor signaling pathway
3'-UTR-mediated mRNA stabilization
regulation of cellular response to heat
protein phosphorylation
positive regulation of tumor necrosis factor production
p38MAPK cascade
mRNA stabilization
inner ear development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support