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Invitrogen
Phospho-MAPKAPK2 (Thr334) Recombinant Rabbit Monoclonal Antibody (MAPKAPK2T334-H2), PE
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Product Details
MA5-37011
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MAPKAPK2T334-H2
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr334 of human phospho MAPKAPK-2.
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation. MAPKAPK2 encodes a member of the Ser/Thr protein kinase family. MAPKAPK2 is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, MAPKAPK2 is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for MAPKAPK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAPK-activated protein kinase 2; MAPKAP kinase 2; mitogen-activated protein kinase-activated protein kinase 2
Gene Aliases: MAPKAP-K2; MK-2; MK2; Rps6kc1
UniProt ID: (Human) P49137, (Mouse) P49138
Entrez Gene ID: (Human) 9261, (Mouse) 17164
MAPK cascade
toll-like receptor signaling pathway
leukotriene metabolic process
inflammatory response
cellular response to DNA damage stimulus
regulation of tumor necrosis factor-mediated signaling pathway
response to lipopolysaccharide
regulation of interleukin-6 production
regulation of tumor necrosis factor production
response to cytokine
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
regulation of mRNA stability
macropinocytosis
vascular endothelial growth factor receptor signaling pathway
3'-UTR-mediated mRNA stabilization
regulation of cellular response to heat
protein phosphorylation
positive regulation of tumor necrosis factor production
p38MAPK cascade
mRNA stabilization
inner ear development
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